Who am I ?

Full professor since 2005 at Paris-Saclay University - Univ. Evry, I have realized a scientific retraining to bioinformatics and computational biology in 2000. Previously, my research topics concerned high performance computing: compilation of parallel languages, parallelization of sparse structures, sparse structure environment for high performance parallel computing. Currently, my research topics are focused on the dynamics of biological networks, network-based game theory and computational methods for network Medicine. I am a part of COSMO Team.

Research Topics

Network property analysis

Theoretical study of biological network contributes to decipher the staggering complexity of cell behavior. The objective is to develop a corpus of theoretical and methodological frameworks to exhibit the properties of biological networks. More precisely, we study the causal analysis of the networks and modularity

Molecular network reprogramming

Network medicine is related to the study of disease and treatment based on molecular network analysis. The transition between healthy and diseased cell state or conversely is interpreted as molecular network reprogramming induced by topological perturbations assimilated to the reprogramming actions. The objective is to infer these actions leading to cell fate modification. We develop a theoretical framework extending the Boolean networks, called the controlled Boolean networks where the network topological actions characterize the controls. The challenge is to automatically infer causal actions to direct the the dynamics of (biological) system towards an expected behavior. More generally, this modeling framework can be applied to a large number of situations related to cell fate reprogramming.

 Master 2 Internships, PHD subject

See the  page of propositions